Lipodystrophy Fund

Lipodystrophy is a rare group of disorders characterized by the loss of body fat (adipose tissue), which can be partial or generalized, inherited or acquired. The main symptoms include abnormal fat distribution, insulin resistance, diabetes, hypertriglyceridemia, and fatty liver disease. The severity varies widely, from mild cases with localized fat loss to severe generalized forms with life-threatening metabolic complications. Common physical features include prominent musculature, enlarged liver and spleen, and acanthosis nigricans. Mental health issues, such as depression and anxiety, are also prevalent due to the impact on physical appearance and quality of life.