Graft-Versus-Host Disease Fund

Graft-versus-host disease (GVHD) is a serious immune-mediated complication of allogeneic stem cell or bone marrow transplantation. It occurs when donor immune cells attack the recipient’s tissues and may present as acute or chronic disease. GVHD is an acquired condition related to transplant and immune compatibility, not a genetic disorder.

GVHD can be long-term or lifelong and commonly affects the skin, gastrointestinal tract, liver, lungs, eyes, and mouth. Symptoms may include skin rashes, diarrhea, liver dysfunction, dry eyes or mouth, joint stiffness, and pulmonary impairment. Ongoing immunosuppressive treatment and monitoring are often required to prevent progressive organ damage and serious infections.

The condition significantly impacts daily functioning and quality of life, often beginning within months of transplant and persisting for years. Individuals frequently need long-term specialty care, infection prevention strategies, and supportive management for organ complications. Frequent medical visits, medication burden, and caregiver involvement are common and place sustained physical, emotional, and financial strain on patients and their families.