Activated PI3K Delta Syndrome Fund

Activated PI3K Delta Syndrome (APDS) is a very rare inherited condition that affects the immune system. It happens because of changes in certain genes that cause the immune system to work incorrectly. People with APDS often get frequent and serious infections, especially in the lungs and sinuses. Over time, this can lead to swollen lymph nodes, enlarged spleen, lung damage, autoimmune problems, and even a higher risk of lymphoma. Many patients struggle with fatigue, poor growth, and missed school or work.

Living with APDS can be challenging. Most people need lifelong treatments like immunoglobulin therapy, antibiotics, and sometimes hospital stays. Some require immune-modulating drugs or even stem cell transplants. Even with care, lung damage and other complications can make everyday life harder—limiting exercise, causing breathing problems, and creating stress about infections and cancer. This often impacts education, jobs, and family life.